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論文・総説

• 論文（2020年代）
• 論文（2010年代）
• 論文（2000年代）
• 論文（1990年代）
• 総説

2025年

• Asahi, K.^a, Hirose, M.^a, Aruga, R.^a, Shimizu, Y.^a, Tajiri, M.^a, Tanaka, T., Adachi, Y., Tanaka, Y., Kaneko, M.K., Kato, Y., Akashi, S., Akiyama, Y., Hizukuri, Y.^*, Kato, T.^*, Nogi, T.^* (2025). ^aequally contributed
  Cryo-EM structure of the bacterial intramembrane metalloprotease RseP in the substrate-bound state. Sci. Adv., 11, 9, eadu0925.
  DOI : 10.1126/sciadv.adu0925
  京都大学HP
  分解酵素は細胞膜の中でタンパク質をヘッドロックして切断する〜基質と結合した膜内タンパク質分解酵素の立体構造を解明〜
• Yokoyama. T.^*, Miyazaki, R., Suzuki, T., Dohmae, N., Nagai, H., Tsukazaki, T., Kubori, T.^*, Akiyama, Y.^* (2025).
  Cleavage cascade of the sigma regulator FecR orchestrates TonB-dependent signal transduction. Proc. Natl. Acad. Sci. U. S. A., 122, 16, e2500366122.
  DOI : 10.1073/pnas.2500366122
  京都大学HP
  細菌が環境中の鉄の存在を「知る」しくみを解明 膜タンパク質の多段階切断を介して、細胞外の情報が細胞内へ伝達される

2024年

• Watanabe, A., Koyano, F., Imai, K., Hizukuri, Y., Ogiwara, S., Ito, T., Miyamoto, J., Shibuya, C., Kimura, M., Toriumi, K., Motono, C., Arai, M., Tanaka, K., Akiyama, Y., Yamano, K., Matsuda, N.^* (2024).
  The origin of esterase activity of Parkinson’s disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA. J. Biol. Chem., 300, 107476.
  DOI : 10.1016/j.jbc.2024.107476
• Ikeda, Y., Miyazaki, R., Tsukazaki, T., Akiyama, Y., and Mori, H.^* (2024).
  Translation arrest cancellation of VemP, a secretion monitor in Vibrio, is regulated by multiple cis and trans factors, including SecY. J. Biol. Chem., 300, 107735.
  DOI : 10.1016/j.jbc.2024.107735

2023年

• Yokoyama, T., Yamagata, Y., Honna, S., Mizuno, S., Katagiri, S., Oi, R., Nogi, T., Hizukuri, Y.^*, and Akiyama, Y.^* (2023).
  S2P intramembrane protease RseP degrades small membrane proteins and suppresses the cytotoxicity of intrinsic toxin HokB. mBio, 14, e0108623.
  DOI : 10.1128/mbio.01086-23

2022年

• Miyazaki, R., Ai, M.^a, Tanaka, N. ^a, Suzuki, T., Dhomae, N., Tsukazaki, T., Akiyama, Y., and Mori, H.^* (2022). ^aequally contributed
  Inner membrane YfgM–PpiD heterodimer acts as a functional unit that associates with the SecY/E/G translocon and promotes protein translocation. J. Biol. Chem., 298, 102572.
  DOI : 10.1016/j.jbc.2022.102572
• Imaizumi, Y.^a, Takanuki, K.^a, Miyake, T.^a, Takemoto, M., Hirata, K., Hirose, M., Oi, R., Kobayashi, T., Miyoshi, K., Aruga, R., Yokoyama, T., Katagiri, S., Matsuura, H., Iwasaki, K., Kato, K., Kaneko, M. K., Kato, Y., Tajiri, M., Akashi, S., Nureki, N., Hizukuri, Y.^*, Akiyama, Y.^*, and Nogi, T.^* (2022). ^aequally contributed
  Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP. Sci. Adv., 8(34), eabp9011.
  DOI : 10.1126/sciadv.abp9011
  京都大学HP
  細胞膜の中ではたらく特殊なタンパク質分解酵素の構造を解明～細菌感染症の新たな治療法の開発へ期待～
• Qiao, Z., Yokoyama, T., Yan, X., Beh, I., Shi, J., Basak, S., Akiyama, Y.^*, and Gao, Y.^* (2022).
  Cryo-EM structure of the entire FtsH-HflKC AAA protease complex. Cell Rep., 39, 110890.
  DOI : 10.1016/j.celrep.2022.110890

2021年

• Miyazaki, R., Watanabe, T., Yoshitani, K., and Akiyama, Y.^* (2021).
  Edge-strand of BepA interacts with immature LptD on the β-barrel assembly machine to direct it to on- and off-pathways. eLife, 10:e70541.
  DOI : 10.7554/eLife.70541
• Yokoyama, T., Niinae, T., Tsumagari, K., Imami, K., Ishihama, Y., Hizukuri, Y.^*, and Akiyama, Y.^* (2021).
  The Escherichia coli S2P intramembrane protease RseP regulates ferric citrate uptake by cleaving the sigma factor regulator FecR. J. Biol. Chem., 296, 100673.
  DOI : 10.1016/j.jbc.2021.100673
• Tamura-Sakaguchi, R., Aruga, R., Hirose, M., Ekimoto, T., Miyake, T., Hizukuri, Y., Oi, R., Kaneko, M. M., Kato, Y., Akiyama, Y., Ikeguchi, M., Iwasaki, K., and Nogi, T.^* (2021).
  Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope tag insertion. Acta Crystallogr. D Struct. Biol., 77, 645-662.
  DOI : 10.1107/S2059798321002527
  京都大学HP
  タンパク質の抗体ラベリング技術を改良し、構造解析をアシスト －電子顕微鏡やX線結晶解析による構造決定を加速化－

2020年

• Miyazaki, R., Akiyama, Y., and Mori, H.^* (2020).
  Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation. eLife, 9, e62623.
  DOI : 10.7554/eLife.62623
• Miyake, T., Hizukuri, Y.^*, and Akiyama, Y^*. (2020).
  Involvement of a membrane-bound amphiphilic helix in substrate discrimination and binding by an Escherichia coli S2P peptidase RseP. Front. Microbiol., 11, 607381.
  DOI : 10.3389/fmicb.2020.607381
• Daimon, Y.^a, Narita, S.^a, Miyazaki, R., Hizukuri, Y., Mori, H., Tanaka, Y., Tsukazaki, T., and Akiyama, Y.^* (2020). ^aequally contributed
  Reversible auto-inhibitory regulation of Escherichia coli metallopeptidase BepA for selective β-barrel protein degradation. Proc. Natl. Acad. Sci. U. S. A. 117, (45) 27989-27996.
  DOI : 10.1073/pnas.2010301117